Hormonal
Adding liraglutide (1.2 or 1.8 mg/day) to maximized metformin and thiazolidinedione (TZD) therapy significantly improves glycemic control (A1C, fasting, and postprandial glucose) and induces dose-dependent weight loss in patients with type 2 diabetes.
If you have Type 2 Diabetes and are already taking metformin and a TZD (like rosiglitazone) but your blood sugar isn't controlled, adding liraglutide (1.2 or 1.8 mg once daily) can significantly lower your A1C and help you lose weight. While you might experience some nausea or stomach issues, these are usually temporary and happen mostly in the first few weeks. This combination is effective for improving blood sugar without causing major low blood sugar episodes.
Liraglutide combined with metformin and a thiazolidinedione is a well-tolerated combination therapy for type 2 diabetes, providing significant improvements in glycemic control.
Why this rating
Large-scale (n=533), double-blind, placebo-controlled, randomized parallel-group trial.
Source
Efficacy and Safety of the Human Glucagon-Like Peptide-1 Analog Liraglutide in Combination With Metformin and Thiazolidinedione in Patients With Type 2 Diabetes (LEAD-4 Met+TZD)
Bernard Zinman et al. · Diabetes Care · 2009
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