Hormonal
Liraglutide (1.8 mg/day) added to metformin and sulfonylurea provides superior glycaemic control and significant weight loss compared to insulin glargine in type 2 diabetes, while maintaining a non-inferior hypoglycaemia risk profile.
If your diabetes is not controlled by metformin and a sulfonylurea, adding once-daily liraglutide (1.8 mg) is a highly effective strategy. It lowers blood sugar better than insulin glargine and helps you lose weight, whereas insulin typically causes weight gain. Be prepared for temporary nausea in the first few weeks, which usually subsides. This treatment requires daily injections but offers superior metabolic benefits compared to basal insulin in this context.
Liraglutide added to metformin and sulfonylurea produced significant improvement in glycaemic control and bodyweight compared with placebo and insulin glargine. The difference vs insulin glargine in HbA1c was within the predefined non-inferiority margin.
Why this rating
Randomized, parallel-group, controlled trial with 581 patients across 17 countries.
Source
Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
on behalf of the Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group et al. · Diabetologia · 2009
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →