Hormonal
Age-related skeletal muscle loss (sarcopenia) is fundamentally driven by 'anabolic resistance,' a blunted muscle protein synthesis response to nutritional and exercise stimuli, compounded by reduced physical activity.
As you age, your muscles become less sensitive to protein and exercise. To maintain muscle, you likely need to consume more protein per meal and engage in resistance training, as your body's natural response to these stimuli is blunted compared to when you were younger.
Ground breaking work more than 10 years ago helped to develop the idea of 'anabolic resistance' to explain the phenomenon of age related muscle loss. The premise being that increases in MPS and suppressions in MPB in response to the key environmental factors regulating muscle maintenance i.e. food intake... and exercise... are blunted compared to younger people.
Why this rating
Supported by multiple meta-analyses and stable isotope tracer studies, though some acute vs chronic discrepancies exist.
Source
The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans
Daniel J. Wilkinson et al. · Ageing Research Reviews · 2018
DOI 10.1016/j.arr.2018.07.005
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