Macro partitioning
A dietary intervention reducing fat intake to approximately 15-20% of calories significantly improves relapse-free survival in women with early-stage breast cancer, with a greater benefit observed in those with estrogen receptor-negative (ER-negative) tumors.
For breast cancer survivors, adopting a low-fat diet (targeting ~15-20% of calories from fat) is a feasible lifestyle change that may improve survival outcomes, particularly for those with ER-negative tumors. This should be done under the guidance of a dietitian to ensure nutritional adequacy, focusing on fat gram counting and self-monitoring without necessarily aiming for weight loss.
A lifestyle intervention reducing dietary fat intake, with modest influence on body weight, may improve relapse-free survival of breast cancer patients receiving conventional cancer management... The dietary intervention had a greater effect on relapse-free survival in women with ER-negative cancer (HR = 0.58; 95% CI = 0.37 to 0.91) than in women with ER-positive disease (HR = 0.85; 95% CI = 0.63 to 1.14).
Why this rating
Randomized controlled trial with large sample size (n=2437), though the primary analysis was borderline significant and the intervention was terminated early.
Source
Dietary Fat Reduction and Breast Cancer Outcome: Interim Efficacy Results From the Women's Intervention Nutrition Study
Rowan T. Chlebowski et al. · JNCI Journal of the National Cancer Institute · 2006
DOI 10.1093/jnci/djj494
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