Hormonal
Type 2 diabetes risk in Europeans is predominantly driven by common genetic variants of modest effect size, with no novel low-frequency variants of moderate-to-strong effect detected despite extensive sample sizes.
This research indicates that for most people of European ancestry, Type 2 Diabetes risk is largely determined by common genetic factors with small individual effects, rather than rare, high-impact mutations. This means lifestyle interventions remain critical because they address the environmental and physiological pathways (insulin secretion, action) that these genes influence, even if the genetic risk itself cannot be changed.
These findings are consistent with the inference... that the T2D-risk signals identified by GWAS are overwhelmingly driven by common causal variants... we found no such low-frequency variant associations in either established or novel loci.
Why this rating
Large-scale meta-analysis of over 150,000 controls and 26,000 cases with rigorous statistical correction.
Source
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Robert A. Scott et al. · Diabetes · 2017
DOI 10.2337/db16-1253
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