Research
Hormonal
The AGEs/RAGE axis contributes to pancreatic beta cell toxicity and apoptosis via oxidative stress and islet amyloid polypeptide (IAPP) aggregation.
Preserving beta cell function is crucial; strategies that reduce AGEs and oxidative stress may help protect pancreatic beta cells.
GoodSupportsHIGH confidence
Hyperglycemia-induced AGEs load in the pancreas contributes to beta cell toxicity via activation of inflammatory cascades and oxidative stress [75]. ... RAGE binds with these toxic IAPP intermediates and leads to the formation of amyloid plaque resulting in pancreatic beta cell toxicity.
Why this rating
Supported by in vitro and in vivo studies cited.
Source
Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives
Mariyam Khalid et al. · Biomolecules · 2022
DOI 10.3390/biom12040542
narrative_reviewCited 801×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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