Hormonal
Mitochondrial dysfunction in skeletal muscle is a consequence, not a cause, of insulin resistance and diabetes, driven by hyperglycemia- and hyperlipidemia-induced oxidative stress (ROS).
Mitochondrial damage in muscle is likely a result of long-term exposure to high blood sugar and fat, not the initial cause of your metabolic issues. Focusing on lowering blood glucose and improving lipid metabolism through diet and activity addresses the root cause of this damage, rather than just trying to 'boost' mitochondria with supplements.
These data suggest that mitochondrial alterations do not precede the onset of insulin resistance and result from increased ROS production in muscle in diet-induced diabetic mice.
Why this rating
Strong mechanistic evidence using multiple animal models (HFHSD, STZ, KKAy) and in vitro cell cultures, though not human clinical trials.
Source
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
C. Bonnard et al. · Journal of Clinical Investigation · 2008
DOI 10.1172/jci32601
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →