Research
Hormonal
Liraglutide (3 mg once daily) produces a mean weight loss of 8% over 56 weeks in patients without diabetes.
If you are prescribed Liraglutide (Saxenda), expect to take a 3 mg injection once daily. This can lead to an 8% reduction in body weight over 56 weeks. Be prepared for potential gastrointestinal side effects like nausea, which can often be managed by eating smaller meals.
GoodSupportsHIGH confidence
Patients without diabetes were able to achieve a mean weight loss of 8% at 56 weeks with liraglutide 3 mg compared to 2% with placebo in the SCALE trial.
Why this rating
Based on the SCALE trial.
Source
Medical Management of Obesity: Current Trends and Future Perspectives
Andrés Calderón et al. · Methodist DeBakey Cardiovascular Journal · 2025
DOI 10.14797/mdcvj.1503
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Semaglutide (2.4 mg once weekly) produces a mean weight loss of 14.9% over 68 weeks in patients with obesity without diabetes.Good
- GLP-1 and GIP receptor agonists reduce the composite incidence of death due to cardiovascular events, nonfatal myocardial infarction, and nonfatal stroke in patients with overweight or obesity.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
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