Research
Hormonal
Pulsatile or intermittent administration of insulin minimizes desensitization and improves glucose utilization compared to continuous insulin exposure.
If you use insulin, mimicking your body's natural pulse-like release (rather than a constant drip) might work better with less insulin. This suggests that advanced delivery methods or timing strategies could improve effectiveness.
GoodSupportsHIGH confidence
The pulsatile administration of insulin (rather than continuous) results in reduced requirements for insulin.
Why this rating
Supported by multiple studies in humans and animals comparing pulsatile vs continuous delivery.
Source
Insulin Resistance and Hyperinsulinemia
Michael H. Shanik et al. · Diabetes Care · 2008
DOI 10.2337/dc08-s264
narrative_reviewCited 790×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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