Hormonal
Insulin and corticosteroids (dexamethasone) act synergistically to induce PPAR-gamma1 and PPAR-gamma2 mRNA expression in isolated human adipocytes.
In fat cells, high levels of insulin and stress hormones (like cortisol/dexamethasone) work together to increase the expression of PPAR-gamma, a key driver of fat cell formation. This suggests that conditions involving both high insulin and high stress/cortisol may promote adipogenesis through this synergistic molecular pathway.
In vitro experiments revealed a synergistic effect of insulin and corticosteroids to induce PPAR-gamma mRNA expression in isolated human adipocytes in culture.
Why this rating
In vitro study on isolated cells; lacks in vivo validation for the specific synergistic mechanism in humans.
Source
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
Antonio Vidal‐Puig et al. · Journal of Clinical Investigation · 1997
DOI 10.1172/jci119424
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