Hormonal
Elevated circulating levels of branched-chain amino acids (BCAAs) are associated with an increased risk of insulin resistance (IR) and type 2 diabetes mellitus (T2DM), acting as biomarkers for these metabolic conditions.
If you are concerned about insulin resistance or type 2 diabetes, simply taking BCAA supplements may not help and could potentially reflect or exacerbate underlying metabolic issues. Focus on overall metabolic health, including diet quality and physical activity, rather than isolated BCAA supplementation, especially if you have obesity or pre-diabetic conditions.
high circulating BCAAs at the baseline were directly associated with risk of cardiovascular diseases (CVDs)... elevated systemic concentrations of certain AAs provided by gut bacteria, in particular BCAAs, have effects in modulating the development of IR and T2DM... higher blood BCAAs levels have been associated with IR
Why this rating
The paper cites multiple prospective human cohorts and mechanistic animal studies linking BCAA levels to IR/T2DM, though it is a review paper summarizing these findings rather than presenting new primary data.
Source
Branched Chain Amino Acids: Beyond Nutrition Metabolism
Cunxi Nie et al. · International Journal of Molecular Sciences · 2018
DOI 10.3390/ijms19040954
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