Macro partitioning
Consumption of sugar-sweetened beverages containing fructose or high fructose corn syrup promotes de novo lipogenesis and triggers inflammatory responses leading to hepatocyte apoptosis, directly contributing to the development of nonalcoholic fatty liver disease (NAFLD).
Limit sugar-sweetened beverages, particularly those with high fructose corn syrup or sucrose. The paper links drinking two average servings daily for six months to the development of NAFLD features. Reducing these beverages is a primary dietary intervention to lower liver fat accumulation.
Consumption of such beverages has increased five-fold in the United States since 1950, and drinking two average size sugar containing beverage servings for 6 mo ends up mirroring many features of NAFLD. It is hypothesized that sugars promote de novo lipogenesis and trigger inflammatory response leading to hepatocyte apoptosis via the c-Jun-N-Terminal pathway.
Why this rating
Based on a review paper citing multiple cohort studies and mechanistic hypotheses, though direct long-term RCT data in the text is summarized rather than primary.
Source
Clinical epidemiology and disease burden of nonalcoholic fatty liver disease
Brandon J. Perumpail et al. · World Journal of Gastroenterology · 2017
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