Hormonal
Plasma levels of the adipokine omentin-1 are significantly decreased in obese and overweight individuals compared to lean individuals, and these levels are inversely correlated with BMI, waist circumference, and insulin resistance.
This research identifies omentin-1 as a biomarker that drops as you gain visceral fat and become insulin resistant. While there is no current clinical test for omentin-1, this finding reinforces that reducing visceral fat (through caloric deficit and exercise) is likely to restore healthy adipokine profiles, including omentin-1, which may improve insulin sensitivity.
Lean subjects had significantly higher plasma omentin 1 levels than obese and overweight subjects... Plasma omentin 1 levels were inversely correlated with BMI, waist circumference, leptin levels, and insulin resistance as measured by homeostasis model assessment.
Why this rating
Study uses a well-characterized, genetically homogeneous population (Amish) with rigorous statistical adjustments for family structure, age, and sex, though it is observational.
Source
Omentin Plasma Levels and Gene Expression Are Decreased in Obesity
Celia M. de Souza Batista et al. · Diabetes · 2007
DOI 10.2337/db06-1506
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →