Hormonal
Subcutaneous truncal fat is the primary driver of obesity-related insulin resistance in men, whereas intraperitoneal and retroperitoneal fat have a significantly lesser role.
For men, where you store fat matters for insulin sensitivity. Subcutaneous fat in the trunk (abdomen) is a stronger predictor of insulin resistance than visceral (intraperitoneal) or retroperitoneal fat. Focus on reducing overall body fat, as this will likely reduce the metabolically active subcutaneous truncal fat, thereby improving insulin sensitivity.
We conclude that subcutaneous truncal fat plays a major role in obesity-related insulin resistance in men, whereas intraperitoneal fat and retroperitoneal fat have a lesser role.
Why this rating
High-quality methodology (hyperinsulinemic euglycemic clamp with glucose turnover) and MRI-based precise fat quantification in a controlled clinical setting.
Source
Relationships of generalized and regional adiposity to insulin sensitivity in men.
Nicola Abate et al. · Journal of Clinical Investigation · 1995
DOI 10.1172/jci118083
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