Research
Hormonal
Leptin decreases hypothalamic AMPK activity, whereas ghrelin increases it, indicating that these hormones regulate food intake by modulating AMPK.
Your body uses hormones like leptin (satiety) and ghrelin (hunger) to control the brain's energy sensor (AMPK). Leptin turns this sensor down to stop eating, while ghrelin turns it up to start eating. Understanding this balance helps explain why hormonal imbalances can disrupt hunger cues.
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In vivo administration of leptin, which leads to a reduction in food intake, decreases hypothalamic AMPK activity. By contrast, injection of ghrelin in vivo, which increases food intake, stimulates AMPK activity in the hypothalamus.
Why this rating
Robust in vivo animal data showing time-dependent changes in enzyme activity and phosphorylation states.
Source
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
Ulrika Andersson‐Hall et al. · Journal of Biological Chemistry · 2004
DOI 10.1074/jbc.c300557200
mechanism_onlyCited 750×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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