Research
Adherence
Moderate or severe gastrointestinal (GI) adverse events during GLP-1 RA treatment are associated with a higher hazard of discontinuation and a lower rate of reinitiation.
GI side effects are a common reason for stopping GLP-1 RA. If you experience moderate or severe GI issues, talk to your provider about management strategies. These side effects are linked to higher discontinuation rates, but they can often be mitigated to help you stay on the medication.
GoodSupportsHIGH confidence
On-treatment moderate or severe incident GI AEs were associated with a higher hazard of discontinuation for patients with and without T2D... moderate or severe GI AEs during initial treatment were associated with a lower rate of reinitiation for patients with and without T2D.
Why this rating
Large cohort study with time-varying covariate modeling for GI events.
Source
Discontinuation and Reinitiation of GLP-1 Receptor Agonists Among US Adults with Overweight or Obesity
Patricia J Rodriguez et al. · medRxiv · 2024
preprint · n=96544Cited 4×
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