Research
Adherence
Moderate or severe gastrointestinal (GI) adverse events during GLP-1 RA treatment are associated with a higher hazard of discontinuation and a lower rate of reinitiation.
GI side effects are a common reason for stopping GLP-1 RA. If you experience moderate or severe GI issues, talk to your provider about management strategies. These side effects are linked to higher discontinuation rates, but they can often be mitigated to help you stay on the medication.
GoodSupportsHIGH confidence
On-treatment moderate or severe incident GI AEs were associated with a higher hazard of discontinuation for patients with and without T2D... moderate or severe GI AEs during initial treatment were associated with a lower rate of reinitiation for patients with and without T2D.
Why this rating
Large cohort study with time-varying covariate modeling for GI events.
Source
Discontinuation and Reinitiation of GLP-1 Receptor Agonists Among US Adults with Overweight or Obesity
Patricia J Rodriguez et al. · medRxiv · 2024
DOI 10.1101/2024.07.26.24311058
preprint · n=96544Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Discontinuation of GLP-1 receptor agonists (GLP-1 RA) is significantly higher and reinitiation is significantly lower in patients without type 2 diabetes (T2D) compared to those with T2D, driven largely by insurance coverage and cost barriers rather than efficacy.Good
- Greater weight loss during treatment is associated with a lower likelihood of discontinuing GLP-1 RA, and weight regain after discontinuation is associated with a higher likelihood of reinitiating treatment.Good
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