Hormonal
Initiation of testosterone therapy (TT) in men under 65 years with a pre-existing history of heart disease is associated with a significantly increased risk of non-fatal myocardial infarction within the first 90 days of prescription.
If you are under 65 but have a history of heart disease, starting testosterone therapy significantly increases your risk of a heart attack in the first three months. This risk is nearly three times higher than baseline. You should discuss this specific risk with your doctor, who may recommend closer monitoring or alternative treatments.
In men under age 65 years, the RR was 2.90 (1.49, 5.62) for those with a history of heart disease
Why this rating
Observational cohort study using administrative claims data; while large and using robust statistical methods (doubly robust estimation), it lacks the controlled conditions of an RCT.
Source
Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men
William D. Finkle et al. · PLoS ONE · 2014
DOI 10.1371/journal.pone.0085805
More from this paper
- Initiation of testosterone therapy (TT) in men aged 65 years and older is associated with a significantly increased risk of non-fatal myocardial infarction within the first 90 days of prescription.Moderate
- Testosterone therapy (TT) does not significantly increase the risk of non-fatal myocardial infarction in men under 65 years without a history of heart disease.Moderate
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