Hormonal
Sir2 (SIRT1 homolog) extends longevity by acting as an NAD-dependent histone deacetylase that maintains chromatin silencing, thereby preventing genomic instability and inappropriate gene expression associated with aging.
While direct human interventions are not yet validated, the mechanism suggests that maintaining metabolic health (which influences NAD+ levels) is crucial for longevity. Calorie restriction or metabolic strategies that preserve NAD+ pools may theoretically support Sir2/SIRT1 activity, promoting genomic stability. Focus on metabolic health rather than just antioxidant intake.
Sir2 is an NAD-dependent histone deacetylase that may link metabolism and silencing in vivo... Sir2 proteins may link metabolic rate to the pace of aging by sensing NAD levels and generating the mandated level of chromatin silencing.
Why this rating
Based on yeast models and biochemical assays; human data is speculative or observational.
Source
Sir2 links chromatin silencing, metabolism, and aging
Leonard Guarente · Genes & Development · 2000
DOI 10.1101/gad.14.9.1021
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