Research
Hormonal
Sirt1 promotes mitophagy (the turnover of defective mitochondria) through mechanisms involving NAD+ levels and potentially the PINK1/Parkin pathway.
Sirt1 activation, potentially through nicotinamide or SRT1720, may promote the removal of damaged mitochondria (mitophagy). This is part of a broader cellular quality control mechanism that may contribute to longevity and health. More research is needed to fully understand how to harness this for therapeutic benefit.
ModerateSupportsMEDIUM confidence
Interestingly, Sirt1 also appears to be important for the turnover of defective mitochondria by mitophagy.
Why this rating
The paper cites several studies linking Sirt1 to mitophagy, but the mechanisms are not fully elucidated and may vary by cell type.
Source
Sirt1 and the Mitochondria
Bor Luen Tang · Molecules and Cells · 2016
DOI 10.14348/molcells.2016.2318
narrative_reviewCited 720×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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