Hormonal
Time-restricted feeding significantly reduces circulating testosterone and IGF-1 levels in resistance-trained males, although this hormonal reduction does not translate to muscle loss or strength deficits in this specific population.
Monitor your strength and body composition, not just blood work. If your TRF protocol lowers your testosterone and IGF-1 but you are still getting stronger and keeping your muscle, the hormonal drop is likely not functionally limiting for you. Do not change your diet based on hormone numbers alone if your performance is stable.
Testosterone and insulin-like growth factor 1 decreased significantly in TRF, with no changes in ND (p=0.0000) in TRF while total leptin decreased (p=0.0397).
Why this rating
Direct measurement of hormones with statistical significance, but limited generalizability to non-athletes or those with existing hormonal issues.
Source
Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males
Tatiana Moro et al. · Journal of Translational Medicine · 2016
DOI 10.1186/s12967-016-1044-0
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →