Hormonal
Exogenous leptin promotes angiogenesis and endothelial cell proliferation by binding to Ob-R receptors and activating tyrosine kinase-dependent pathways (specifically Erk1/2).
This research suggests that high levels of leptin, common in obesity, may actively fuel the growth of new blood vessels in fat tissue. This creates a feedback loop where more fat leads to more leptin, which builds more blood vessels, allowing even more fat storage. Managing leptin levels through weight loss may help reverse this vascular support for adipose tissue.
These results indicate that leptin, via activation of the endothelial Ob-R, generates a growth signal involving a tyrosine kinase-dependent intracellular pathway and promotes angiogenic processes.
Why this rating
Strong in vitro and in vivo (CAM) mechanistic data, but lacks human clinical trials confirming this specific pathway's dominance in obesity.
Source
Leptin, the Product of Ob Gene, Promotes Angiogenesis
Anne Bouloumié et al. · Circulation Research · 1998
DOI 10.1161/01.res.83.10.1059
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