Research
Hormonal
Cellular senescence in adipose tissue contributes to obesity-associated dysfunction through the secretion of pro-inflammatory factors (SASP) and impairment of angiogenesis.
Obesity can cause fat cells to age prematurely and secrete harmful substances that damage surrounding tissue. Managing obesity may help reduce this cellular aging and its negative effects.
GoodSupportsHIGH confidence
Senescent cells are highly metabolic and exhibit a senescence-associated secretory phenotype (SASP), producing factors that have profound effects on neighboring cells such as proinflammatory cytokines... VEGF, MMPs, and PDGF-AA.
Why this rating
Supported by genetic mouse models and human studies.
Source
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis
Clair Crewe et al. · Journal of Clinical Investigation · 2017
DOI 10.1172/jci88883
narrative_reviewCited 717×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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