Research
Hormonal
Short-term intensive insulin therapy administered at diagnosis of type 2 diabetes can restore beta-cell function and induce temporary remission.
If you have just been diagnosed with type 2 diabetes, ask your doctor about short-term intensive insulin therapy. This approach can 'rest' your pancreas, improve its function, and potentially put your diabetes into temporary remission, especially if caught early.
GoodSupportsHIGH confidence
Among the interventions to preserve or 'rejuvenate' beta-cells, short-term intensive insulin therapy of newly diagnosed type 2 diabetes will improve beta-cell function, usually leading to a temporary remission time.
Why this rating
The paper cites clinical evidence of effects on human beta-cell function, though it notes reversibility is limited to early stages.
Source
β-Cell Failure in Diabetes and Preservation by Clinical Treatment
B L Wajchenberg · Endocrine Reviews · 2007
DOI 10.1210/10.1210/er.2006-0038
narrative_reviewCited 715×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Glucotoxicity and lipotoxicity are major factors causing progressive beta-cell failure in type 2 diabetes through apoptosis.Strong
- Thiazolidinediones (TZDs) preserve beta-cell mass and function by reducing apoptosis and islet amyloid, acting via PPAR-gamma activation.Good
- GLP-1 receptor agonists (e.g., exenatide, liraglutide) and DPP-IV inhibitors preserve beta-cell mass by stimulating proliferation, neogenesis, and inhibiting apoptosis.Moderate
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