Hormonal
Lower serum levels of glycine and lysophosphatidylcholine (LPC) 18:2, combined with higher acetylcarnitine C2, predict the development of impaired glucose tolerance (IGT) and type 2 diabetes (T2D) years before clinical onset, independent of standard risk indicators like fasting glucose and HbA1c.
Current standard blood tests (fasting glucose, HbA1c) may not detect metabolic risk until it is advanced. Emerging research suggests that specific metabolite levels (glycine, LPC, acetylcarnitine) can predict diabetes risk years in advance. If you have risk factors, discuss advanced metabolic screening with your provider, as early detection allows for lifestyle interventions (diet/exercise) that can prevent or delay the onset of Type 2 Diabetes.
Lower levels of glycine and LPC were found to be predictors not only for IGT but also for T2D, and were independently confirmed in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort.
Why this rating
Large-scale prospective population-based cohort (KORA, n>4000) with replication in an independent cohort (EPIC-Potsdam), adjusting for multiple confounders.
Source
Novel biomarkers for pre‐diabetes identified by metabolomics
Rui Wang‐Sattler et al. · Molecular Systems Biology · 2012
DOI 10.1038/msb.2012.43
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