Research
Macro partitioning
Influx of free fatty acids (FFAs) and triglyceride-rich lipoproteins into skeletal muscle induces inflammation and insulin resistance via activation of TLR4, PKC, and JNK pathways.
High levels of circulating fats, especially saturated fats, can flood into muscle cells, causing inflammation and blocking insulin. Managing blood fat levels through diet (reducing saturated fats) and exercise can help prevent this lipid-induced insulin resistance.
GoodSupportsHIGH confidence
In obesity, elevated levels of circulating FFAs... lead to increased FA influx into SM, which not only induces inflammation in immune cells... and myocytes in muscle, but also causes insulin resistance in myocytes.
Why this rating
Strong evidence from multiple studies linking FFAs to inflammation and insulin resistance.
Source
Skeletal muscle inflammation and insulin resistance in obesity
Huaizhu Wu et al. · Journal of Clinical Investigation · 2017
narrative_reviewCited 670×
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