Hormonal
SGLT-2 inhibitors increase the risk of genital infections, while GLP-1 receptor agonists may increase the risk of severe gastrointestinal events.
Be aware of potential side effects: SGLT-2 inhibitors can increase genital yeast infections, and GLP-1 agonists can cause nausea or GI issues. These are common and manageable, but you should discuss prevention strategies (like hygiene for SGLT-2 or slow dose titration for GLP-1) with your doctor before starting.
SGLT-2 inhibitors caused genital infection (high certainty), whereas GLP-1 receptor agonists might cause severe gastrointestinal events (low certainty).
Why this rating
High certainty for genital infection, low certainty for GI events.
Source
Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials
Suetonia C. Palmer et al. · BMJ · 2021
DOI 10.1136/bmj.m4573
More from this paper
- SGLT-2 inhibitors and GLP-1 receptor agonists reduce all-cause mortality, cardiovascular mortality, non-fatal myocardial infarction, and kidney failure in patients with type 2 diabetes, with absolute benefits scaling with baseline cardiovascular and renal risk.Weak
- SGLT-2 inhibitors are superior to GLP-1 receptor agonists for reducing hospital admissions for heart failure, while GLP-1 receptor agonists are superior for reducing non-fatal stroke.Weak
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