Research
Hormonal
Plasma ceramide levels correlate with plasma TNF-α concentrations, suggesting a link between lipid accumulation and systemic inflammation in type 2 diabetes.
Inflammation and fat metabolism are connected in type 2 diabetes. High levels of certain fats (ceramides) in your blood are associated with higher levels of inflammatory markers (TNF-α). Reducing inflammation and managing fat metabolism may help address both issues.
GoodSupportsHIGH confidence
Plasma TNF-α was correlated with C18:1 (r = 0.55, P < 0.005) and C18:0 (r = 0.47, P < 0.02) ceramide subspecies.
Why this rating
Same study limitations as N1, but the correlation with TNF-α adds a layer of mechanistic plausibility supported by literature cited.
Source
Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance
Jacob M. Haus et al. · Diabetes · 2008
DOI 10.2337/db08-1228
cross_sectional · n=27Cited 667×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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