Hormonal
Intermittent administration of senolytic drugs (Dasatinib + Quercetin) or genetic clearance of senescent cells alleviates obesity-induced metabolic dysfunction, including insulin resistance and glucose intolerance, in obese mice.
This research suggests that targeting senescent cells (cells that have stopped dividing and secrete inflammatory factors) using specific drug combinations (like Dasatinib and Quercetin) or genetic methods can improve metabolic health in obesity. While not yet a standard human treatment, it highlights senolytics as a potential future therapy for obesity-related diabetes and inflammation.
Here, we show that reducing senescent cell burden in obese mice, either by activating drug-inducible “suicide” genes driven by the p16Ink4a promoter or by treatment with senolytic agents, alleviates metabolic and adipose tissue dysfunction.
Why this rating
High-quality preclinical evidence using multiple transgenic mouse models and senolytic drugs, though human data is limited to pilot trials mentioned in discussion.
Source
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
Allyson K. Palmer et al. · Aging Cell · 2019
DOI 10.1111/acel.12950
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