Hormonal

Peripheral endocannabinoid system overactivity in adipose and pancreatic tissues directly contributes to obesity-related metabolic dysregulation, including hyperinsulinemia, lipogenesis, and hypoadiponectinemia, independent of central appetite control.

This research suggests that obesity involves a dysregulated signaling system in fat and pancreatic cells that promotes fat storage and insulin resistance, regardless of how much you eat. While this paper does not prescribe a specific diet or exercise routine, it highlights that targeting these peripheral pathways (e.g., via medications like rimonabant, though withdrawn) addresses the root hormonal drivers of metabolic syndrome. For current practice, this underscores the importance of interventions that improve insulin sensitivity and reduce visceral fat, as these may help normalize endocannabinoid signaling.