Hormonal
High-dose aspirin (approx. 7 g/day for 2 weeks) improves glucose metabolism in type 2 diabetes by inhibiting the IKKβ serine kinase pathway, thereby reducing hepatic glucose production and enhancing peripheral insulin sensitivity.
High-dose aspirin (approx 7g/day) significantly improves blood sugar control in type 2 diabetes by targeting inflammation (IKKβ). However, due to significant side effects like tinnitus and gastric risks, it is not recommended for routine treatment. The key takeaway is that targeting the IKKβ pathway is a valid strategy for treating insulin resistance.
High-dose aspirin treatment resulted in a ~25% reduction in fasting plasma glucose... Aspirin treatment also resulted in a ~20% reduction in basal rates of hepatic glucose production and a ~20% improvement in insulin-stimulated peripheral glucose uptake... these data support the hypothesis that IKKβ represents a new target for treating type 2 diabetes mellitus.
Why this rating
Small sample size (n=9) and short duration (2 weeks), but utilizes rigorous hyperinsulinemic-euglycemic clamps.
Source
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
Ripudaman S. Hundal et al. · Journal of Clinical Investigation · 2002
DOI 10.1172/jci14955
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