Hormonal
Long-term weight gain (5 kg or more) over a 10-year period significantly increases the incidence of diabetes mellitus in US adults, with risk increasing proportionally to the magnitude of weight gain.
Maintaining a stable weight is a powerful tool for diabetes prevention. If you are currently gaining weight, even modestly (5 kg or 11 lbs), your risk of developing diabetes increases significantly. The more you gain, the higher the risk. Focus on preventing weight gain rather than waiting for obesity to develop.
Among the entire cohort, weight gain was associated with increased risk for diabetes... The hazard ratios were 2.11... for participants who gained 5-<8 kg... 2.57... for participants who gained 11-<20 kg, and 3.85... for participants who gained 20 kg or more compared with participants whose weights remained relatively stable.
Why this rating
Large national cohort (n=8,545), long follow-up (10+ years), but diabetes diagnosis relied on self-report and records rather than direct glucose testing.
Source
Weight Change and Diabetes Incidence: Findings from a National Cohort of US Adults
E. S. Ford et al. · American Journal of Epidemiology · 1997
DOI 10.1093/oxfordjournals.aje.a009256
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