Research
Hormonal
Timed melatonin administration is indicated to reduce symptoms of jet lag disorder and improve sleep following travel across multiple time zones, with immediate-release formulations in doses of 0.5 to 5 mg showing efficacy.
Take 0.5 to 5 mg of immediate-release melatonin daily. Start up to 3 days before your flight and continue for up to 5 days after arriving at your destination. This helps reset your body clock and improves sleep quality during travel.
WeakSupportsHIGH confidence
Melatonin administered at the appropriate time is indicated to reduce symptoms of jet lag and improve sleep following travel across multiple time zones. [7.4.2.2] (Standard)
Why this rating
Supported by multiple Level 1 and Level 2 double-blind, placebo-controlled field trials.
Source
Practice Parameters for the Clinical Evaluation and Treatment of Circadian Rhythm Sleep Disorders
Timothy I. Morgenthaler et al. · SLEEP · 2007
DOI 10.1093/sleep/30.11.1445
clinical_guidelineCited 623×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →