Hormonal
A 9-month intervention of 1500 mg/day curcumin extract (75-85% curcuminoids) prevents progression to Type 2 Diabetes in prediabetic adults, reducing incidence to 0% compared to 16.4% in placebo, while improving beta-cell function and insulin sensitivity.
If you are prediabetic, taking 1500 mg of a standardized curcumin extract daily (split into two doses) for 9 months may significantly reduce your risk of developing Type 2 Diabetes compared to lifestyle changes alone. This specific extract (75-85% curcuminoids) was shown to improve insulin sensitivity and beta-cell function with minimal side effects. Consult your doctor before starting, especially if you take other medications.
After 9 months of treatment, 16.4% of subjects in the placebo group were diagnosed with T2DM, whereas none were diagnosed with T2DM in the curcumin-treated group. In addition, the curcumin-treated group showed a better overall function of b-cells, with higher HOMA-b (61.58 vs. 48.72; P < 0.01) and lower C-peptide (1.7 vs. 2.17; P < 0.05).
Why this rating
Randomized, double-blinded, placebo-controlled clinical trial with a large sample size (n=240) and clear statistical significance, though limited to a specific demographic (Thai prediabetics).
Source
Curcumin Extract for Prevention of Type 2 Diabetes
Somlak Chuengsamarn et al. · Diabetes Care · 2012
DOI 10.2337/dc12-0116
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