Research
Hormonal
Upregulation of PGC-1α enhances mitochondrial antioxidant defense by increasing the expression of genes such as MnSOD, catalase, and peroxiredoxin, thereby protecting cells from oxidative damage.
Engage in activities that boost PGC-1α, such as exercise and cold exposure, to naturally increase the expression of powerful mitochondrial antioxidants like MnSOD and catalase.
GoodSupportsHIGH confidence
PGC-1α regulates the expression of mitochondrial antioxidant genes, including manganese superoxide dismutase, catalase, peroxiredoxin 3 and 5, uncoupling protein 2, thioredoxin 2, and thioredoxin reductase and thus prevents oxidative injury and mitochondrial dysfunction.
Why this rating
Well-supported by multiple studies cited in the review.
Source
PGC-1<i>α</i>, Inflammation, and Oxidative Stress: An Integrative View in Metabolism
Sergio Rius‐Pérez et al. · Oxidative Medicine and Cellular Longevity · 2020
DOI 10.1155/2020/1452696
narrative_reviewCited 614×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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