Hormonal
High-intensity aerobic exercise (75% VO2max) increases markers of oxidative stress (8-OHdG and MDA-LDL) without improving endothelium-dependent vasodilation.
If you exercise at high intensity (75% of your max capacity), be aware that it may increase oxidative stress in your body. While this doesn't necessarily mean you are harming your health, it does not provide the same endothelial benefits as moderate exercise. For optimal vascular health, moderate intensity is preferred.
High-intensity exercise increases plasma concentrations of 8-hydroxy-2'-deoxyguanosine (from 6.7±1.1 to 9.2±2.3 ng/mL; P<0.05) and serum concentrations of malondialdehyde-modified low-density lipoprotein (from 69.0±19.5 to 82.4±21.5 U/L; P<0.05)... whereas moderate exercise tended to decrease both indices of oxidative stress.
Why this rating
Clear measurement of oxidative stress markers with statistical significance, though limited to a specific high-intensity group.
Source
Effect of Different Intensities of Exercise on Endothelium-Dependent Vasodilation in Humans
Chikara Goto et al. · Circulation · 2003
DOI 10.1161/01.cir.0000080893.55729.28
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