Research
Hormonal
Ultrasound-defined NAFLD is associated with a two- to five-fold increased risk of developing Type 2 Diabetes (T2DM), independent of lifestyle and metabolic confounders.
A diagnosis of fatty liver on an ultrasound is a strong warning sign for developing Type 2 Diabetes, independent of your weight. You should undergo regular glucose monitoring (HbA1c or OGTT) even if you do not currently have diabetes, as resolving the fatty liver can significantly reduce this risk.
GoodSupportsHIGH confidence
USS-defined NAFLD is associated with a two to five fold risk of developing T2DM after adjustment of several lifestyle and metabolic confounders.
Why this rating
Supported by multiple large prospective population-based studies and meta-analyses, though some conflicting data exists regarding mild steatosis.
Source
Extrahepatic complications of nonalcoholic fatty liver disease
Matthew J. Armstrong et al. · Hepatology · 2013
DOI 10.1002/hep.26717
narrative_reviewCited 603×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Nonalcoholic fatty liver disease (NAFLD), particularly the NASH subtype and advanced fibrosis, is an independent risk factor for increased incidence and mortality of cardiovascular disease (CVD).Good
- NAFLD, particularly biopsy-proven NASH, is associated with a greater prevalence of Chronic Kidney Disease (CKD) and an increased risk of incident CKD.Moderate
- Nonalcoholic steatohepatitis (NASH) is associated with a significantly higher risk of colorectal adenomas and cancer compared to simple steatosis or healthy controls.Moderate
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