Hormonal
Obesity and post-diagnosis weight gain in breast cancer patients are associated with significantly increased risks of disease recurrence and mortality.
For breast cancer patients, maintaining a healthy weight or losing weight if overweight is critical for reducing the risk of recurrence and death. This is not just about aesthetics; it is a clinical priority supported by strong observational data and hormonal mechanisms. Patients should engage in weight loss programs combining diet, physical activity, and behavioral therapy.
women with breast cancer who are overweight or gain weight after diagnosis are found to be at greater risk for breast cancer recurrence and death compared with lighter women.
Why this rating
Based on a systematic review of 34 studies (29,460 women) and a meta-analysis showing statistically significant hazard ratios.
Source
Weight Loss in Breast Cancer Patient Management
Rowan T. Chlebowski et al. · Journal of Clinical Oncology · 2002
DOI 10.1200/jco.2002.20.4.1128
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- Obesity in breast cancer patients is mediated by hormonal profiles that stimulate breast cancer growth, including higher estrogen, androgen, and insulin/IGF-1 levels.Good
- Weight gain after breast cancer diagnosis, particularly following adjuvant chemotherapy, is a common occurrence that negatively impacts survival and recurrence risk.Good
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