Macro partitioning
In healthy young adults undergoing nutritional transition, a higher-fat diet (40% energy) compared to a lower-fat diet (20% energy) causes unfavorable shifts in gut microbiota (decreased Faecalibacterium/Blautia, increased Bacteroides/Alistipes), reduces short-chain fatty acids, and increases plasma proinflammatory markers.
If you are young and healthy but your diet is shifting towards higher fat intake, be aware that increasing fat to 40% of your calories (while keeping calories constant) may negatively impact your gut bacteria and increase inflammation markers like CRP. Switching to a lower fat diet (20% of calories) was associated with more favorable gut bacteria (higher Faecalibacterium and Blautia) and lower inflammation.
Higher-fat consumption by healthy young adults whose diet is in a state of nutrition transition appeared to be associated with unfavourable changes in gut microbiota, faecal metabolomic profiles and plasma proinflammatory factors, which might confer adverse consequences for long-term health outcomes.
Why this rating
Randomized controlled feeding trial with isocaloric diets and comprehensive metabolomic/microbiome analysis, though limited to young, healthy adults.
Source
Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial
Yi Wan et al. · Gut · 2019
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