Hormonal
High-level gastrointestinal expression of bacterial bile salt hydrolase (BSH) enzymes significantly reduces host weight gain, plasma cholesterol, and liver triglycerides in mice.
This research suggests that increasing the activity of bile salt hydrolase (BSH) in the gut, potentially through specific probiotic bacteria (like certain Lactobacillus strains), may help reduce weight gain and lower cholesterol. While this is a mouse study, it highlights the gut microbiome as a target for metabolic health. You might explore probiotics known for BSH activity, but consult a doctor before making changes, especially if you have existing metabolic conditions.
High-level expression of BSH in conventionally raised mice resulted in a significant reduction in host weight gain, plasma cholesterol, and liver triglycerides, demonstrating the overall impact of elevated BSH activity on host physiology.
Why this rating
Controlled in vivo experiments in gnotobiotic and conventionally raised mice with statistical significance (P < 0.05) and consistent results across multiple metrics (weight, cholesterol, triglycerides).
Source
Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
Susan A. Joyce et al. · Proceedings of the National Academy of Sciences · 2014
DOI 10.1073/pnas.1323599111
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