Research
Hormonal
Rimonabant, a CB1 receptor antagonist, was withdrawn due to an increased risk of serious psychiatric adverse events, including depression and suicidal ideation.
Rimonabant was withdrawn from the market because it significantly increased the risk of depression and suicidal thoughts compared to placebo.
GoodRefutesHIGH confidence
The adverse psychiatric events were observed in 26% of the participants in the rimonabant group compared with 14% in the placebo group in the same 4 studies
Why this rating
Based on the RIO program (4 phase 3 trials, >6,000 patients).
Source
Anti-Obesity Drugs: A Review about Their Effects and Safety
Jun Goo Kang et al. · Diabetes & Metabolism Journal · 2012
DOI 10.4093/dmj.2012.36.1.13
narrative_reviewCited 587×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Orlistat is the only currently available anti-obesity drug for long-term management due to its favorable cardiovascular safety profile compared to withdrawn agents like sibutramine and rimonabant.Good
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