Hormonal
Overexpression of the SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth in vivo by directly deacetylating and inhibiting the transcriptional activity of beta-catenin.
This research suggests that the biological pathway involving SIRT1 may help protect against colon cancer by turning off a key driver of tumor growth (beta-catenin). While this paper uses genetic overexpression in mice, it supports the idea that maintaining healthy SIRT1 function (potentially through calorie restriction or other means) might be beneficial for cancer prevention. It does not recommend specific supplements or doses for humans.
We show that SIRT1 deacetylates b-catenin and suppresses its ability to activate transcription and drive cell proliferation. Moreover, SIRT1 promotes cytoplasmic localization of the otherwise nuclear-localized oncogenic form of b-catenin.
Why this rating
Strong in vivo evidence using transgenic mouse models and human tissue microarrays, though it is a single study.
Source
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Ron Firestein et al. · PLoS ONE · 2008
DOI 10.1371/journal.pone.0002020
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