Research
Hormonal
Small, soluble IAPP oligomers (prefibrillar assemblies) are the primary cytotoxic species responsible for beta-cell death, whereas mature amyloid fibrils are less cytotoxic.
Therapies should target the early formation of soluble IAPP aggregates, not just the mature amyloid deposits, as the early aggregates are the primary cause of cell death.
GoodQualifiesHIGH confidence
The most potent cytotoxic effect of human IAPP occurs soon after peptide reconstitution, when IAPP is in small oligomeric aggregates... These mature amyloid deposits are less cytotoxic than the small aggregates
Why this rating
Consistent in vitro and animal model data.
Source
Islet Amyloid: A Critical Entity in the Pathogenesis of Type 2 Diabetes
Rebecca L. Hull et al. · The Journal of Clinical Endocrinology & Metabolism · 2004
DOI 10.1210/jc.2004-0405
narrative_reviewCited 584×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Islet amyloid polypeptide (IAPP) aggregation into small soluble oligomers causes beta-cell death via membrane disruption and oxidative stress, contributing to the loss of beta-cell mass in type 2 diabetes.Good
- Insulin resistance and obesity increase the secretory demand on beta-cells, which accelerates the formation of cytotoxic IAPP aggregates and amyloid deposition.Good
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