Research
Adherence
Estrogen suppresses food intake by acting on hypothalamic neurons (POMC, NPY) and reducing orexigenic signals like Neuropeptide Y (NPY) and Ghrelin.
Estrogen helps regulate your appetite by signaling to your brain to eat less. When estrogen drops, this signal weakens, potentially leading to increased hunger.
GoodSupportsHIGH confidence
Estrogens directly act on POMC neurons and regulate their cellular activity. Recent findings provide additional support for the importance of ERα POMC neurons and the suppression of food intake.
Why this rating
Supported by animal studies showing hyperphagia in ER-deficient mice.
Source
Estrogen Deficiency and the Origin of Obesity during Menopause
Fernando Lizcano et al. · BioMed Research International · 2014
systematic_reviewCited 576×
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