Hormonal
Pharmacological inhibition or genetic ablation of enzymes controlling sphingolipid synthesis (specifically Serine Palmitoyltransferase and Dihydroceramide Desaturase 1) ameliorates insulin resistance, atherosclerosis, and cardiomyopathy in rodent models.
This research suggests that the type of fat you consume matters more than just the total amount, specifically regarding how it affects your body's insulin sensitivity. Saturated fats appear to trigger the production of specific lipids (ceramides) that block insulin action, contributing to metabolic disease. While this is proven in animals, it implies that dietary quality, particularly the ratio of saturated to unsaturated fats, is a critical lever for metabolic health.
researchers have found that pharmacological inhibition or genetic ablation of enzymes controlling sphingolipid synthesis in rodents ameliorates each of these conditions.
Why this rating
Strong evidence from multiple in vivo rodent models (knockout mice, pharmacological inhibition) showing consistent beneficial effects, though human data is observational/correlational.
Source
Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism
William L. Holland et al. · Endocrine Reviews · 2008
DOI 10.1210/er.2007-0025
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