Hormonal
Elevated white blood cell count (WBC), serving as a marker of chronic low-grade inflammation, predicts the development of type 2 diabetes and is associated with a worsening of insulin sensitivity independent of adiposity.
High white blood cell counts are a warning sign for future insulin resistance and type 2 diabetes, even in people who are not yet obese. This suggests that chronic, low-grade inflammation is a key driver of metabolic health. To mitigate this risk, focus on reducing systemic inflammation through anti-inflammatory dietary patterns (rich in omega-3s, fiber, and polyphenols), managing stress, and treating any underlying chronic infections or conditions, rather than focusing solely on weight loss.
A high WBC predicts a worsening of insulin action and the development of type 2 diabetes in Pima Indians. These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes.
Why this rating
Prospective longitudinal study with rigorous metabolic clamping (gold standard for insulin sensitivity) and adjustment for multiple confounders.
Source
High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes
Barbora Vozarova et al. · Diabetes · 2002
DOI 10.2337/diabetes.51.2.455
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