Research
Hormonal
Reactive oxygen species (ROS) derived from NADPH oxidase activation contribute to the progression of atherosclerosis in diabetic patients by promoting endothelial dysfunction, inflammation, and smooth muscle cell proliferation.
Managing diabetes helps reduce the risk of atherosclerosis by lowering ROS production. Genetic factors also play a role in vulnerability, so comprehensive management of blood sugar and blood pressure is important for vascular health.
GoodSupportsHIGH confidence
NADPH oxidase-derived ROS play a crucial role in the development of atherosclerosis in human as well as in mice.
Why this rating
Supported by animal models, human genetic association studies, and clinical observations, but largely mechanistic reviews rather than interventional trials.
Source
Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
Hideaki Kaneto et al. · Mediators of Inflammation · 2010
DOI 10.1155/2010/453892
narrative_reviewCited 567×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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