Research
Hormonal
High-dose aspirin (approx. 7 g/day) improves glucose metabolism in type 2 diabetes by inhibiting the IKKβ serine kinase pathway, thereby reducing hepatic glucose production and enhancing peripheral insulin sensitivity.
This study proves that inhibiting the IKKβ pathway improves insulin sensitivity in type 2 diabetes. However, high-dose aspirin is too toxic for routine use. The practical takeaway is that IKKβ is a valid therapeutic target for developing safer diabetes medications, rather than using aspirin itself.
GoodSupportsHIGH confidence
High-dose aspirin treatment resulted in a ~25% reduction in fasting plasma glucose... Aspirin treatment also resulted in a ~20% reduction in basal rates of hepatic glucose production and a ~20% improvement in insulin-stimulated peripheral glucose uptake... these data support the hypothesis that IKKβ represents a new target for treating type 2 diabetes mellitus.
Why this rating
Small sample size (n=9) and short duration (2 weeks), but utilizes rigorous hyperinsulinemic-euglycemic clamps.
Source
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
Ripudaman S. Hundal et al. · Journal of Clinical Investigation · 2002
DOI 10.1172/jci0214955
crossover · n=9Cited 566×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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