Research
Hormonal
Brown Adipose Tissue (BAT) activation is not essential for FGF19 to increase metabolic rate and reverse obesity/diabetes, as FGF19 remains effective in mice with diminished BAT (UCP-DTA mice).
You don't need 'active' brown fat for FGF19 to help with weight and blood sugar. It works through other pathways, primarily in the liver.
GoodRefutesHIGH confidence
In contrast to the control UCP-DTA mice, the doubly transgenic mice (FGF19 and UCP-DTA) did not become obese... and had normal-fed glucose levels... Thus, it appears that BAT is not essential for FGF19 to produce decreased adiposity and improved glucose homeostasis.
Why this rating
Uses a specific genetic model (UCP-DTA) to isolate the role of BAT.
Source
Fibroblast Growth Factor 19 Increases Metabolic Rate and Reverses Dietary and Leptin-Deficient Diabetes
Ling Fu et al. · Endocrinology · 2004
DOI 10.1210/en.2003-1671
mechanism_onlyCited 565×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Administration of recombinant human Fibroblast Growth Factor 19 (FGF19) increases metabolic rate and reverses diet-induced and leptin-deficient diabetes in mice without reducing food intake.Good
- FGF19 increases metabolic rate and improves glucose homeostasis by increasing fatty acid oxidation and decreasing liver triglycerides, mediated by the suppression of Acetyl CoA Carboxylase 2 (ACC2) and increased leptin receptor expression in the liver.Good
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