Pharmacological inhibition of mTOR (e.g., rapamycin) extends lifespan in mice, but systemic blockade in humans may accelerate sarcopenia and frailty due to impaired muscle protein synthesis, requiring tissue-specific targeting.

Pharmacologic inhibition of mTOR (with rapamycin) was also shown to extend median and maximal life span in mice... human skeletal muscle from older adults has been shown to have impaired mTOR complex 1 activation and protein synthesis in response to an acute resistance exercise bout... systemic blockade of the mTOR complex 1 pathway could elicit an aging phenotype in skeletal muscle and accelerate the onset of sarcopenia and frailty.