Hormonal
Transdermal estrogen does not significantly increase the risk of venous thromboembolism in postmenopausal women, unlike oral estrogen.
If you are using transdermal estrogen (patches or gels), your risk of blood clots is not significantly increased compared to women not using hormones. This makes transdermal estrogen a safer choice than oral estrogen for postmenopausal women concerned about thromboembolism, especially those with other risk factors like obesity or genetic mutations.
Meta-analysis of observational studies showed that oral oestrogen but not transdermal oestrogen increased the risk of venous thromboembolism... odds ratio... in current users of transdermal oestrogen was 1.2 (0.9 to 1.7).
Why this rating
Based on fewer observational studies for transdermal route compared to oral; no RCTs specifically for transdermal VTE risk were found.
Source
Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis
Marianne Canonico et al. · BMJ · 2008
DOI 10.1136/bmj.39555.441944.be
More from this paper
- Current use of oral estrogen increases the risk of venous thromboembolism in postmenopausal women, with the highest risk occurring during the first year of treatment.Strong
- The combination of oral estrogen use with prothrombotic mutations (Factor V Leiden or Prothrombin G20210A) or obesity significantly enhances the risk of venous thromboembolism.Strong
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